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抑癌基因Ｗａｆｌ／Ｃｉｐｌ／ｐ２１（Ｗｉｌｄ┐ｔｙｐｅ┐ｐ５３┐ａｃｔｉｖａｔｅｄｆｒａｇｍｅｎｔ／ＣＤＫ┐ｉｎｔｅｒａｃｔｉｎｇｐｒｏｔｅｉｎ１／ｐ２１）既与肿瘤抑制作用密切相关，又能通过抑制周期素┐周期素依赖激酶（Ｃｙｃｌｉｎ┐ＣＤＫｓ）复合物活性，协调细胞周期、ＤＮＡ复制与修复之间的关系，从而将肿瘤抑制作用与细胞周期控制过程紧密相连。ｐ２１基因的发现、克隆及其在细胞周期控制与肿瘤发生中有重要作用
The tumor suppressor gene Wafl/Cipl/p21 (Wild┐type┐p53┐activated fragment/CDK┐interactingprotein1/p21) is closely related to tumor inhibition and can inhibit the activity of Cyclin┐CDKs complex , Coordinating the relationship between cell cycle, DNA replication and repair, thereby closely linking tumor suppression with cell cycle control. Discovery and cloning of p21 gene and its important role in cell cycle control and tumorigenesis