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目的 研究ING1、p2 1 /WAF1、p53基因蛋白在胃癌组织中的表达意义及相互关系。方法 对 71例胃癌组织应用Envision免疫组化法 ,检测 p33ING1 、p2 1 /WAF1、p53的表达情况 ,分析其相关性 ,结合临床病理因素 ,探讨胃癌发生、进展及预后的关系。结果 p33ING1 与p2 1 /WAF1、p53表达有相关性 (P <0 .0 5) ,p33ING1 表达率为 62 .0 % (44/71 ) ,与正常组织相比呈低表达 ,与胃癌的浸润、淋巴结转移、远隔转移、分化程度有相关性 (P <0 .0 1 ) ;p2 1 /WAF1表达率为54 .9% (39/71 ) ,与胃癌浸润相关 (P <0 .0 5) ;p53表达为 63 .4 % (45/71 ) ,与浸润及淋巴结转移相关 (P <0 .0 1 )。结论 ING1是抑癌基因 ,其蛋白p33ING1 在胃癌中低表达 ,对胃癌的发生、发展可能起重要作用 ,p33ING1 、p2 1 /WAF1、p53表达可作为判断胃癌恶性程度及预后的重要指标
Objective To study the expression and relationship of ING1, p2 1 / WAF1 and p53 gene proteins in gastric cancer. Methods Envision immunohistochemistry was used to detect the expression of p33ING1, p2 1 / WAF1 and p53 in 71 cases of gastric cancer. The correlation was analyzed. The relationship between the expression of p33ING1, p21 / WAF1 and p53 and the clinicopathological factors were analyzed. Results The expression of p33ING1 was correlated with the expression of p21 / WAF1 and p53 (P <0.05), and the expression of p33ING1 was 62.0% (44/71). The expression of p33ING1 was lower than that of normal tissues, Lymph node metastasis, distant metastasis and differentiation (P <0.01). The expression rate of p21 / WAF1 was 54.9% (39/71), which was correlated with gastric cancer infiltration (P <0.05) ; p53 expression was 63.4% (45/71), which was correlated with infiltration and lymph node metastasis (P <0.01). CONCLUSIONS: ING1 is a tumor suppressor gene whose expression of p33ING1 protein is low in gastric cancer and may play an important role in the occurrence and development of gastric cancer. The expression of p33ING1, p21 / WAF1 and p53 may be used as an important index to judge the malignancy and prognosis of gastric cancer