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目的通过对52例唐氏综合征产前超声检查结果分析,探讨超声检查在唐氏综合征产前诊断中的意义。方法回顾性分析2013年1月至2015年12月经产前诊断确诊的52例唐氏综合征超声检查结果。结果 52例唐氏综合征胎儿中产前超声检查未发现明显异常的11例,占21.2%;单发异常20例,占38.5%;多发异常21例,占40.4%。超声结构畸形中心脏结构畸形最多发生15例,其次超声软指标鼻骨未显示发生11例,第三超声软指标心室强光斑发生6例。结论产前超声胎儿结构异常和单个、多个软指标与唐氏综合征有相关性,需结合血清学筛查结果、孕妇年龄等因素综合评估,进行侵入性产前诊断可提高唐氏综合征胎儿的检出率。
Objective To analyze the results of prenatal ultrasonography in 52 cases of Down Syndrome and explore the significance of ultrasonography in prenatal diagnosis of Down’s syndrome. Methods A retrospective analysis of 52 cases of Down’s syndrome diagnosed by prenatal diagnosis from January 2013 to December 2015 was performed. Results Among the 52 fetuses with Down Syndrome, 11 cases (21.2%) had no prenatal ultrasonography, 20 cases were single abnormality (38.5%), and 21 cases were multiple abnormality (40.4%). Ultrasound structural abnormalities in the structure of the heart malformation occurred in up to 15 cases, followed by ultrasound soft index of the nasal bone did not appear in 11 cases, the third ultrasound soft tissue ventricular light spot in 6 cases. Conclusion Prenatal ultrasound fetal structural abnormalities and single, multiple soft index is associated with Down Syndrome, combined with serological screening results, the age of pregnant women and other factors comprehensive assessment of invasive prenatal diagnosis can improve Down’s syndrome Fetal detection rate.