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目的:探讨桂枝茯苓胶囊辅助治疗输卵管阻塞性不孕的临床疗效及对肿瘤坏死因子-α(TNF-α)的影响。方法:选取2015年6月—2016年12月本院收治的输卵管阻塞性不孕患者82例为研究对象,随机分为治疗组与对照组,对照组患者给予输卵管通液术治疗,治疗组患者在输卵管通液术的基础上给予桂枝茯苓胶囊辅助治疗,在治疗结束后对两组的临床疗效进行评价,对比治疗前后两组患者中医证候积分、治疗后输卵管通畅情况及血清TNF-α水平。结果:治疗组与对照组患者的总有效率分别为92.68%、78.05%,治疗组患者的总有效率显著高于对照组(P<0.05);两组血清TNF-α水平在治疗前对比无显著差异(P>0.05),治疗后两组患者血清TNF-α水平均较治疗前显著降低(P<0.05),且治疗组患者血清TNF-α水平低于对照组(P<0.05);两组患者治疗前中医证候积分对比无显著差异(P>0.05),治疗后两组中医证候积分均显著降低,且治疗组患者低于对照组(P<0.05);治疗组患者输卵管通畅率显著高于对照组,输卵管通而不畅、积水及堵塞率显著低于对照组(P<0.05)。结论:桂枝茯苓胶囊辅助宫腔镜输卵管通液术治疗输卵管阻塞性不孕的可显著提高临床疗效,并改善输卵管通畅程度及血清TNF-α水平,值得临床推广。
Objective: To investigate the clinical efficacy of Guizhi Fuling Capsule in the treatment of obstructive tubal obstruction and its effect on tumor necrosis factor-α (TNF-α). Methods: 82 patients with tubal obstructive infertility admitted to our hospital from June 2015 to December 2016 were selected as the research object and randomly divided into treatment group and control group. Patients in the control group were treated with tubal fluid infusion. Patients in the treatment group The treatment of Guizhi Fuling Capsule was given on the basis of tubal fluidization. The clinical efficacy of the two groups was evaluated after the treatment. The scores of TCM syndromes, the tubal patency and the levels of serum TNF-α Level. Results: The total effective rates of the treatment group and the control group were 92.68% and 78.05%, respectively. The total effective rate of the treatment group was significantly higher than that of the control group (P <0.05). The levels of TNF-α in the two groups before treatment (P <0.05). After treatment, the levels of serum TNF-α in both groups were significantly lower than those before treatment (P <0.05), and the level of serum TNF-α in the treatment group was lower than that in the control group (P <0.05) There was no significant difference in TCM syndrome scores before treatment between two groups (P> 0.05). After treatment, the scores of TCM syndromes in both groups were significantly lower than those in the control group (P <0.05); tubal patency rate Significantly higher than the control group, tubal obstruction and sluggish, water and clogging rate was significantly lower than the control group (P <0.05). Conclusion: Guizhi Fuling capsules assisted hysteroscopic tubal fluid treatment of tubal obstruction infertility can significantly improve the clinical efficacy and improve tubal patency and serum levels of TNF-α, worthy of clinical promotion.