半个世纪以来,青霉素的主要对象菌是肺炎球菌、链球菌、淋球菌和脑膜炎球菌。金葡菌对青霉素不敏感。淋球菌的耐药性在1983年达高峰,此后下降。肺炎球菌通常仍敏感。脑膜炎球菌的耐药性也有所出现。尽管如此,青霉素G的适应症仍是肺炎球菌、脑膜炎球菌、化脓性链球菌、非肠球菌性链球菌、微需氧链球菌、淋球菌等引起的感染,以及梅毒、急性钩端螺旋体病及Lyme螺旋体病。大多数口腔菌和厌氧菌,包括放线菌 For half a century, the main target strains of penicillin are pneumococcus, streptococcus, gonococcus and meningococcus. Staphylococcus aureus insensitive to penicillin. Neisseria gonorrhoeae resistance peaked in 1983 and declined thereafter. Pneumococci are usually still sensitive. Meningococcal resistance has also emerged. Nevertheless, the indications of penicillin G are still pneumococcal, meningococcal, Streptococcus pyogenes, non-enterococci Streptococcus, Microbiopes aeruginosa, Neisseria gonorrhoeae and other infections, as well as syphilis, acute leptospirosis And Lyme spirochetes. Most oral and anaerobic bacteria, including actinomycetes