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应用免疫组化ＡＢＣ方法研究７５例乳腺癌冰冻组织表皮生长因子受体（ＥＧＦＲ）的表达，结合临床资料和ＥＲ、ＰＲ测定结果进行分析，探讨ＥＧＦＲ表达与乳腺癌预后的关系。结果表明，ＥＧＦＲ阳性３０例（４０％），ＥＧＦＲ表达与肿瘤大小、腋淋巴结状况，临床分期和年龄无关，与ＥＲ、ＰＲ存在着显著的负相关（Ｐ＜０．００５）。全组中位随诊时间为６０个月，ＥＧＦＲ阳性组术后总生存率明显低于阴性组（Ｐ＜０．００１）。在无腋淋巴结转移的病例中，ＥＧＦＲ阳性组和阴性组术后生存情况也有显著差异（Ｐ＜０．０１），提示ＥＧＦＲ表达与乳腺癌不良的预后有关。调整分析乳腺癌有关的预后因素，各组病例中均以ＥＧＦＲ表达阳性组的预后为差，说明ＥＧＦＲ对乳腺癌预后具有独立的作用，不受其他因素的影响。经Ｃｏｘ模型多因素分析显示，ＥＧＦＲ和腋淋巴结受累与否是对乳腺癌术后生存情况有显著性影响的两个因素。
The immunohistochemical ABC method was used to study the expression of epidermal growth factor receptor (EGFR) in frozen tissues of 75 cases of breast cancer. The clinical data and ER and PR results were analyzed to explore the relationship between EGFR expression and prognosis of breast cancer. The results showed that EGFR positive in 30 cases (40%), EGFR expression and tumor size, axillary lymph node status, clinical stage and age have nothing to do, there is a significant negative correlation with ER, PR (P <0.005). The median follow-up time was 60 months in the whole group, and the overall survival rate in the EGFR-positive group was significantly lower than that in the negative group (P<0.001). In cases with no axillary lymph node metastasis, there was also a significant difference in postoperative survival between the EGFR positive group and the negative group (P<0.01), suggesting that EGFR expression is associated with a poor prognosis of breast cancer. Adjusting the prognostic factors related to breast cancer, the prognosis of EGFR-positive patients in each group was poor, indicating that EGFR has an independent effect on the prognosis of breast cancer and is not affected by other factors. Multivariate analysis by Cox model showed that EGFR and axillary lymph node involvement were two factors that had a significant effect on the survival of breast cancer patients.