论文部分内容阅读
本文报告了２８例尘肺伴发肺癌的病理组织学及超微结构改变，一般特点是：发病年龄偏早（６４％在４１～４９岁确诊为肺癌），有中度以上吸烟史，预后差。病理特点是全部病例除尘性病变外均有支气管树上皮的慢性损害（变性和增生），肺内纤维化病变周围的肺泡上皮增生。２８例肺癌的光、电镜诊断符合率为３９．３％，不符合占６０．７％，电镜诊断结果为：单纯鳞癌４例、单纯腺癌３例、单纯Ａｐｕｄ肿瘤１例，单纯间皮瘤２例、鳞腺（或腺鳞）混合癌１０例、鳞癌和Ａｐｕｄ瘤混合３例、腺癌和Ａｐｕｄ瘤混合２例、鳞腺癌和Ａｐｕｄ瘤混合３例。上述全部肿瘤均来源于支气管表面上皮（基底细胞、粘液颗粒细胞和Ａｐｕｄ细胞）和间皮细胞。电镜诊断反映了瘤细胞不同方向分化和不同配比的组合。
This paper reports the histopathology and ultrastructural changes of lung cancer associated with pneumoconiosis in 28 cases. The general characteristics are: early age of onset (64% diagnosed as lung cancer in 41 to 49 years old), moderate to moderate smoking history, and poor prognosis. The pathological features were all chronic lesions (denaturation and hyperplasia) of bronchial tree epithelium outside the dedusting lesions of all cases, and alveolar epithelial hyperplasia around pulmonary fibrotic lesions. The diagnostic accuracy of light and electron microscopy in 28 cases of lung cancer was 39.3%, which was inconsistent with 60.7%. Electron microscopic findings were: simple squamous cell carcinoma in 4 cases, simple adenocarcinoma in 3 cases, simple Apud tumor in 1 case, and simple mesothelium There were 2 cases of tumors, 10 cases of squamous gland (or adenosquamous) mixed carcinoma, 3 cases of squamous cell carcinoma and Apud tumor, 2 cases of adenocarcinoma and Apud tumor, 3 cases of squamous adenocarcinoma and 3 cases of Apud tumor. All of the above tumors were derived from bronchial surface epithelium (basal cells, mucinous granulosa cells, and Apud cells) and mesothelial cells. Electron microscopy diagnosis reflects the different orientation differentiation and different combinations of tumor cells.