近年来我们对药物代谢过程及药物代谢结果的认识有很大的进展。由早先认为的消除、解毒过程进而认识到所给药物经代谢改变可能生成作用更强或具有不同药理特性的化合物。这些活性代谢物可随母体药物的服用日益积聚,甚至个别代谢物较母体药物活性更强且易蓄积。在这种情况下,用药的目的主要是用该药活性更强的代谢产物,代谢物的 In recent years, our understanding of the process of drug metabolism and drug metabolism has made great progress. By the earlier thought of elimination, the detoxification process, in turn, recognized that the given drug may undergo metabolic changes to produce compounds that are more potent or have different pharmacological properties. These active metabolites may accumulate with the administration of the parent drug, and even individual metabolites may be more active and accumulate than the parent drug. In this case, the main purpose of medication is to use the drug more active metabolites, metabolites