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基因重组碱性成纤维细胞生长因子(basic fibroblastgrowth factor,bFGF)能刺激成纤维细胞和内皮细胞的增殖和分化,而这些细胞涉及鼓膜愈合的全部过程,国外有资料报道已在动物实验中证实.我科曾把bFGF与吡哌酸(PPA)粉混合,喷洒在外伤造成的鼓膜穿孔边缘,发现鼓膜穿孔愈合速度明显加快,效果满意,现报道如下.1 材料与方法自1995年2月至1997年2月,收治28例外伤性鼓膜穿孔患者,年龄19～45岁,平均年龄26.5岁.将患者随机分为A、B两组,各14例.A组男11例,女3例;左耳8例,右耳6例.B组男10例,女4例;左耳9例,右耳
Recombinant basic fibroblast growth factor (bFGF) can stimulate the proliferation and differentiation of fibroblasts and endothelial cells. These cells involve the entire process of healing of the tympanic membrane. Data reported in foreign countries have been confirmed in animal experiments. Our department once mixed bFGF and PPA powder and sprayed on the perforation edge of the tympanic membrane caused by trauma and found that the perforation of the tympanic membrane was accelerated obviously with satisfactory results and is reported as follows.1 Materials and Methods From February 1995 to 1997 In February, 28 patients with traumatic perforation of the tympanic membrane, aged 19 to 45 years, mean age 26.5 years old.The patients were randomly divided into A and B groups, 14 cases in each group.A group of 11 males and 3 females; left 8 cases of ear, 6 cases of right ear, Group B male 10 cases, female 4 cases; left ear in 9 cases, right ear