以往报道表明 ,褪黑激素 (melatonin ,MEL)对癫活动有作用 ,但结果并不一致。有实验表明MEL有抗作用 ,也有证据支持MEL有促作用。本文用海马内微量注射的方法 ,观察了MEL对青霉素所致样发作 (penicillin inducedseizures ,PIS)的影响 ,并对其与受体的可能作用作了探讨。发现 ,预先给予MEL对PIS有抑制作用 ,且该效应具有剂量依赖性。褪黑激素的作用可被Ⅰ型受体拮抗剂luzindole部分阻断 ,而Ⅱ型受体拮抗剂prazosine对此无影响。结果表明 ,MEL对PIS有预防作用 ,该作用可能与MELⅠ型受体部分有关 Previous reports showed that melatonin (MEL) has an effect on epileptic activity, but the results are not consistent. Some experiments have shown that MEL has an anti-otic effect, and there is evidence that MEL has a pro-damaging effect. In this study, the effect of MEL on penicillin induced seizures (PIS) was observed by microinjection into the hippocampus. The possible role of MEL on penicillin induced seizures (PIS) was also discussed. It was found that pretreatment of MEL inhibited PIS and the effect was dose-dependent. The effect of melatonin was partially blocked by luzindole, a type I receptor antagonist, while prazosine, a type II receptor antagonist, had no effect on it. The results show that MEL has a preventive effect on PIS, the role may be related to MEL Ⅰ receptor part