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现知LH脉冲式分泌对于维持正常卵巢功能是不可缺少的,而这种分泌方式又受GnRH的周期性释放所调控.上述关系如被干扰,就能引起下丘脑性闭经.已有报道,脉冲式给予GnRH可以诱发排卵,并可获得妊娠.作者对两例下丘脑性无排卵病例用微型自动滴注GnRH泵,诱发排卵与妊娠,同时用放射免疫测定有关激素变化,并用超声显象测量滤泡直径,证实了上述给药方式的效果.微型自动滴注泵可束在腰部,带有合成GnRH3.2mg,溶于8ml生理水中.通过导管将药滴入前臂静脉,每90分钟一次,每次50μl,含15～20μg GnRH.自动泵可工作10日,通常维持到排卵后
It is now known that LH pulsatile secretion is essential for the maintenance of normal ovarian function, and this secretion is regulated by the periodic release of GnRH, which, if disturbed, can cause hypothalamic amenorrhea. It has been reported that pulsations Given GnRH can induce ovulation and pregnancy can be obtained.The author of two cases of hypothalamic anovulation cases with mini-automatic infusion of GnRH pump induced ovulation and pregnancy, while radioimmunoassay related hormone changes, and measured by ultrasound imaging filter Bubble diameter, confirmed the effect of the above mode of administration.A mini automatic drip pump can be bundled in the waist, with synthetic GnRH3.2mg, dissolved in 8ml of physiological water.Drugs through the catheter into the forearm vein once every 90 minutes, each Times 50μl, containing 15 ~ 20μg GnRH.Automatic pump can work for 10 days, usually until after ovulation