由于促性腺激素释放激素(GnRH)可以脉冲样方式给药,使它成为下丘脑性闭经患者的促排卵剂。在本工作中,作者探讨给药途径、治疗持续时间以及是否需支持黄体期的问题。在本工作中,下丘脑性闭经患者连续在二个周期的卵泡期中接受同样的治疗。用一种定时输注器,经皮下每2小时给予GnRH 20μg,直到超声波显示有排卵证据时停药。每个患者在第一周期的黄体期中,每隔三天肌内注射hCG2500IU以维持黄体期。第二周期则不用hCG。在给予hCG的周期中,根据基础体温与孕酮 Because gonadotropin-releasing hormone (GnRH) can be administered in a pulsatile manner, it becomes an ovulation stimulant in patients with hypothalamic amenorrhea. In this work, the authors explored the route of administration, the duration of treatment, and the need to support the luteal phase. In this work, patients with hypothalamic amenorrhea receive the same treatment continuously for two cycles of the follicular phase. GnRH 20 μg was administered subcutaneously every 2 hours with a time-laden injector until withdrawal of evidence of ovulation on ultrasound. Each patient was intramuscularly injected with hCG2500IU every third day to maintain the luteal phase during the luteal phase of the first cycle. The second cycle is not hCG. During the cycle of hCG administration, basal body temperature and progesterone were used