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广东省是脊髓灰质炎（脊灰）高发区，１９８５～１９９３年各年都有流行，历年流行的脊灰野毒株均为Ｉ型病毒。在历年来分离的流行病毒株中，选择不同时期的Ｉ型脊灰病毒２２株做ＰＣＲ－ＲＦＬＰ分析，发现广东省脊灰Ｉ型流行株共有９种电泳图谱类型，显示了在基因水平上的多样性。根据ＰＣＲ－ＲＦＬＰ分析结果又选择了其中９株代表株，对其ＶＰ１编码区３００个核苷酸进行序列分析，结果显示各年的流行株间序列有差异。此结果表明，广东省脊灰流行与多种基因型脊灰病毒的存在有关，但口服脊灰疫苗（ＯＰＶ）形成的免疫屏障可阻断脊灰野病毒的传播。
Guangdong Province is polio (polio) high incidence area, and has been popular in all years from 1985 to 1993. All the poliovirus strains that are prevalent in the past years are type I viruses. Among the epidemic strains isolated over the years, 22 strains of type I poliovirus at different stages were selected for PCR-RFLP analysis. It was found that there were 9 types of electrophorogram in Guangdong Province poliovirus type I epidemic strains, showing that at the gene level Diversity. According to the result of PCR-RFLP analysis, 9 representative strains were selected, and 300 nucleotides of VP1 coding region were sequenced. The results showed that there were differences among the epidemic strains in different years. This result indicates that the prevalence of poliovirus in Guangdong Province is related to the presence of multiple genotypes of poliovirus. However, the immune barrier formed by oral poliovirus vaccine (OPV) can block the transmission of poliovirus.