Patients with schizophrenia undergo changes in brain plasticity.In the present study,we characterized motor cortical-striatal plasticity in such patients.Compared with the potentiation following high-frequency repetitive transcranial magnetic stimulation in the control group,the patients demonstrated impaired plasticity of corticostriatal motor-evoked potentials recorded from hand muscles.Notably,the loss of cortical plasticity was correlated with impaired motor learning in a rotary pursuit task.Moreover,the loss of plasticity was correlated with the symptoms of schizophrenia.The results suggest that the progression of schizophrenia is accompanied by altered cortical plasticity and functioning.