Dear Editor,rnThe mammalian cerebral cortex,responsible for all higherorder brain functions,is organized into six layers of neurons that form distinct projections and connections within and outside the cortex.During cortical development,neural progenitor cells (NPCs) in the proliferative ventricular zone (VZ) and subventricular zone (SVZ) of the dorsal telencephalon produce projection neurons that migrate toward the pial surface to form the cortical plate (CP).New-born neurons adopt a multipolar morphology with dynamic morphological rearrangement within the SVZ and the lower intermediate zone (IZ).This multipolar stage ends when cells extend a dominant pia-directed leading process and transform to a characteristic bipolar morphology [1-3].This process is known as the multipolar-to-bipolar transition.After migrating radially to their correct position in the CP,neurons further develop a dendritic arborization,the basis of synaptic connections [4,5].