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我院自1989年起采用胞二磷胆碱治疗妊娠剧吐,取得较好效果,现报道如下。 1 临床资料 1.1 一般资料:30例均为初孕妇,年龄21～28岁,排除了其它原因引起的呕吐,经补液及其它对症治疗3天以上呕吐不缓解。实验室检查:尿酮体30例均为阳性,其中(++)以上者24例。血清钾:3.1～4.0mmol/L者25例,4.1～4.2mmol/L者5例。血清钠:128～134mmol/L者21例,135～143mmol/L者9例。二氧化碳结合力16～20mmol/L者22例中,21～25mmol/L者8例。血清氯30例均在正常范围之内。 1.2 治疗方法:停用一切止吐药物,以胞二磷胆碱500mg加5％葡萄糖500ml静滴,每日1次,呕吐停止后连用3天。由于本组病例大部分不能进食,所以尚须补液、调整水电解质及酸碱平衡。 1.3 结果:本组30例用药后呕吐当日停止者26例,2日呕吐停止者4例,平均静滴胞二磷胆碱4.2天。
Our hospital since 1989 with citicoline treatment of hyperemesis gravidarum, achieved good results, are reported below. 1 Clinical data 1.1 General information: 30 cases are pregnant women, aged 21 to 28 years old, ruled out other causes of vomiting, rehydration and other symptomatic treatment of vomiting over 3 days do not ease. Laboratory tests: urine ketone body 30 cases were positive, of which (++) above 24 cases. Serum potassium: 3.1 ~ 4.0mmol / L in 25 cases, 4.1 ~ 4.2mmol / L in 5 cases. Serum sodium: 21 cases of 128 ~ 134mmol / L, 135 ~ 143mmol / L in 9 cases. Carbon dioxide binding force of 16 ~ 20mmol / L in 22 cases, 21 ~ 25mmol / L in 8 cases. Serum chlorine in 30 cases were within the normal range. 1.2 treatment: disable all antiemetic drugs to citicoline 500mg plus 5% glucose 500ml intravenous infusion once daily, vomiting once stopped for 3 days. As most of this group of patients can not eat, so still rehydration, adjust the water and electrolyte and acid-base balance. 1.3 Results: The group of 30 patients stopped vomiting the day after treatment in 26 cases, 2 vomiting stopped in 4 cases, the average intravenous citicoline 4.2 days.