论文部分内容阅读
目的 :评价Bcl 2及Bax基因蛋白在听神经瘤组织中的表达及意义。方法 :取库存石蜡包埋组织标本 ,40例听神经瘤分作复发组、囊变组及对照组 ,采用SABC法免疫组化半定量检测Bcl 2及Bax蛋白在听神经瘤组织中的表达。结果 :Bcl 2阳性者 2 7例 ,多见于AntoniA区 ;Bax阳性者 2 6例 ,多见于AntoniB区。不同组间Bcl 2与Bax表达的相对构成有差别 (χ2 =6 64 ,P <0 0 5 )。结论 :Bcl 2 /Bax蛋白表达水平的相对构成可能与听神经瘤临床生物学行为有关
Objective: To evaluate the expression and significance of Bcl-2 and Bax in acoustic neuroma tissue. Methods: Paraffin-embedded tissue samples were collected from 40 patients with acoustic neuroma, divided into recurrence group, cystic change group and control group. The expression of Bcl-2 and Bax protein in acoustic neuroma tissues was detected by immunohistochemical SABC method. Results: There were 27 cases of Bcl-2 positive in the area of AntoniA, and 26 cases of Bax-positive in the area of AntoniB. There was a difference in the relative composition of Bcl 2 and Bax between different groups (χ 2 = 6 64, P <0 05). Conclusions: The relative composition of Bcl 2 / Bax protein expression may be related to the clinical biological behavior of acoustic neuroma