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目的 探讨不同听力分期梅尼埃病(Menieredisease,MD)患者眼肌前庭诱发肌源性电位(ocularvestibularevokedmyogenicpotential,oVEMP)及冷热试验(calorictest)的特征及临床意义。方法 对确诊的MD患者55例(52.8±15.8岁),按MD听力分期标准分为1期9例(48.8±13.8岁),2期9例(46.0±16.3岁),3期23例(50.3±13.5岁),4期14例(53.5±16.2岁),均行oVEMP检测及冷热试验,分析其结果。结果 1、2、3、4期MD患者oVEMP异常率分别为55.6%(5/9)、66.7%(6/9)、78.3%(18/23)、78.6%(11/14),冷热试验异常率分别为22.2%(2/9)、33.3%3/9)、78.3%(18/23)、85.7%(12/14)。可引出oVEMP的1、2、3、4期MD患者振幅分别为4.3±4.0、3.5±2.3、2.5±2.4、1.3±0.5μV。结论 MD患者oVEMP及冷热试验异常率随其听力受损程度加重呈上升趋势,oVEMP振幅呈下降趋势,提示椭圆囊与水平半规管的损伤加重。
Objective To investigate the characteristics and clinical significance of ocularvestibularevokedmyogenicpotential (oVEMP) and caloric test in patients with different stages of Meniere’s disease (MD). Methods Fifty-five patients (52.8 ± 15.8 years) with MD were divided into 9 stages (48.8 ± 13.8 years), 2 stage 9 (46.0 ± 16.3 years), 3 stage 23 cases (50.3 ± 13.5 years old) and 4 cases (53.5 ± 16.2 years old). The results of oVEMP test and hot and cold test were analyzed. Results The abnormal rates of oVEMP in patients with stage 1, 2, 3 and 4 MD were 55.6% (5/9), 66.7% (6/9), 78.3% (18/23) and 78.6% (11/14) The abnormal rates were 22.2% (2/9), 33.3% (3/9), 78.3% (18/23) and 85.7% (12/14) respectively. The amplitudes of MDS patients with stage 1, 2, 3 and 4 MDRs that induced oVEMP were 4.3 ± 4.0, 3.5 ± 2.3, 2.5 ± 2.4 and 1.3 ± 0.5 μV, respectively. Conclusion The oVEMP and the abnormality rate of cold-heat test in MD patients increase with the increase of hearing loss, and the amplitude of oVEMP decreases. It suggests that the damage of oval capsule and horizontal semicircular canal is aggravated.