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目的探讨儿童肝损害的病因和临床分析。方法对2008—2009年收住的肝功能损害患儿120例进行病因分析,并比较不同程度肝功能损害患儿的病因组成是否不同及评价护肝治疗的价值。结果①并发肝损害患儿120例中,明确具体病因的以乙型肝炎并发肝损害最高(16.7%),巨细胞病毒(cytomegalovims,CMV)感染并发肝损害次之(10.8%),戊型肝炎并发肝损害最低(0.8%),其中有43.3%肝损害患儿未找到原因。②中、重度肝功能损害患儿大多由肝炎病毒感染所致,而轻度肝功能损害患儿大多由非肝炎病毒所致。③轻度肝损害89例,护肝治疗与否,差异无统计学意义(P>0.05);中、重度肝损害31例,护肝治疗与否,差异有统计学意义(P<0.05)。结论儿科许多疾病都可能并发肝功能损害,应引起临床医生的高度重视,中、重度肝损害护肝治疗有助于肝功能的恢复。
Objective To investigate the etiology and clinical analysis of liver damage in children. Methods A total of 120 children with liver dysfunction admitted to our hospital from 2008 to 2009 were analyzed for etiology, and the etiology of children with different degrees of liver dysfunction were compared and the value of hepatoprotective therapy was evaluated. Results ① Among the 120 children with liver injury, the most specific causes were hepatitis B complicated with liver damage (16.7%), cytomegalovims (CMV) complicated with liver damage (10.8%), hepatitis E Concurrent liver damage the lowest (0.8%), of which 43.3% of children with liver damage did not find the cause. ② In children with severe or severe liver dysfunction, mostly caused by hepatitis virus infection, and mild liver dysfunction in children mostly caused by non-hepatitis virus. ③ mild liver damage in 89 cases, liver protection or not, the difference was not statistically significant (P> 0.05); moderate and severe liver damage in 31 cases, liver protection or not, the difference was statistically significant (P <0.05). Conclusion Many pediatric diseases may be complicated by liver dysfunction, which should arouse the attention of clinicians. The treatment of moderate and severe liver damage and liver protection is helpful to the recovery of liver function.