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本文应用醋纤薄膜电泳法测定正常人、肝胆疾病和急性病毒性心肌炎患者共244例的血清乳酸脱氢酶(LDH)同功酶。结果心肌炎时67%的病例LDH_1>LDH_2,无1例LDH_5>LDH_4;肝病患者则大部分LDH_5>LDH_4,在排除肌病的情况下,LDH_5升高提示肝病存在,且LDH_5的升高幅度和异常率与肝病的严重程度有关;胆系疾病很少LDH_5>LDH_4;肝癌多数病例LDH_5>LDH_4,且LDH总活力往往明显升高。作者认为分析LDH同功酶谱有助于肝胆疾病的诊断和鉴别诊断。
In this paper, a total of 244 cases of serum lactate dehydrogenase (LDH) isoenzyme in normal human, hepatobiliary disease and acute viral myocarditis were determined by using cellulose acetate membrane electrophoresis. Results In myocarditis, 67% of cases had LDH_1> LDH_2, none of LDH_5> LDH_4 and most of patients with liver disease had LDH_5> LDH_4. In the absence of myopathy, elevated LDH_5 suggested the existence of liver disease, and the increase and abnormality of LDH_5 The rate is related to the severity of liver disease; LDH_5> LDH_4 in biliary diseases; LDH_5> LDH_4 in most cases of liver cancer, and the total LDH activity tends to be significantly higher. The authors believe that the analysis of LDH isoenzymes contribute to the diagnosis and differential diagnosis of hepatobiliary disease.