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自40年代用DDS以来,继氯苯吩嗪和利福平之后,抗麻风又有一些新药相继出现,正在试验中。一、氟喹诺酮(Fluoroquinolones)该药与萘啶酸为一类,先用于抗泌尿道感染,其抗菌机理是抑制细菌的DNA旋转酶,其衍生物有Norfloxacin、Ano-xocin、ciprofloxacin、Pefloxacin(甲氟哌酸)和ofloxacin(氟嗪酸)等。据报ciprofloxacin杀菌力较Norflo-xacin和Cinoxacin高4～32倍,但耐药率也高,为10~(-7)～10~(-9);用于MDT优于其它抗生素。有人比较了norfloxacin、Ciprofloxacin对100多种分枝菌的杀菌力(不包括麻风菌),后者对结核和偶然分枝菌的最小抑菌浓度(Mic)较前者高4倍。1987年Guelpa等报道ciprofloxacin治疗艾滋病人的avium分枝菌感染有效,
Since DDS was used in the 40’s, some new anti-leprosy drugs appeared one after another following the trials of clopiroxazine and rifampicin and are undergoing trials. First, fluoroquinolones (Fluoroquinolones) This drug and nalidixic acid as a class, first used in anti-urinary tract infection, the antibacterial mechanism of inhibition of bacterial DNA gyrase, the derivatives of Norfloxacin, Ano-xocin, ciprofloxacin, Pefloxacin ( Mefloxacin) and ofloxacin (ofloxacin) and the like. Ciprofloxacin is reported to be 4 to 32 times more bactericidal than Norflo-xacin and Cinoxacin, but its drug resistance is also high, ranging from 10 -7 to 10 -9. MDT is superior to other antibiotics. It was compared norcloxacin, Ciprofloxacin bactericidal effect on more than 100 kinds of mycobacteria (excluding leprosy), which was 4 times higher than the former on the minimum inhibitory concentration (Mic) of tuberculosis and occasional mycobacteria. 1987 Guelpa et al reported that ciprofloxacin treatment of AIDS in patients with avium mycobacterial infection effective,