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THE bioactivity study of C_(60) and its relative derivatives is of considerable importance.BecauseC_(60) itself is a non-polar molecule and very difficult to dissolve in common polar solvents,its ap-plication in biochemistry field is greatly impeded.Successful preparation of some water-solubleC_(60) derivatives will be helpful.Friedman found that a water-soluble C_(60) derivative,[HOCO-