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淋巴因子(Lymphokinc)的名称最早出现在1969年,起初特指参与迟发型变态反应的淋巴细胞发生细胞免疫或在体外激活后,从细胞上清液中分离出的一些蛋白因子。根据这些蛋白质不同的功能,曾命名了一大申名称,如移动抑制因子(MIF),巨噬细胞激活因子(MAF),DNA合成抑制因子(SIRS),皮肤反应因子(SRF)等,几乎有上百种之多。以后发现,其它细胞如单核细胞,都可以分泌这类因子。名称不同作用也不同的因子,实际可能是同一种蛋白。这些因子也不仅仅对淋巴细胞起作用。80年代以后,仅用细胞上清液做淋巴因子来源的时代过去了。用重组DNA技术(分子克隆
The name of Lymphokinc first appeared in 1969, initially referring to some of the protein factors isolated from the cell supernatant after cellular immunization of lymphocytes involved in late-onset allergy or after in vitro activation. According to the different functions of these proteins, a big name has been named, such as MIF, MAF, SIRS, SRF, etc. Hundreds of hundreds. Later found that other cells, such as monocytes, can secrete such factors. The names of different effects of different factors, the actual may be the same protein. These factors do not act on lymphocytes either. After the 1980s, the era of lymphoid origin alone using cell supernatants has passed. Using recombinant DNA technology (molecular cloning