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目的探讨FK506的肝毒性。方法报告2例肾移植术后应用FK506后,出现转氨酶、胆红素升高。结果1例仅停药后肝功恢复;另1例经停药,保肝治疗后恢复。结论FK506可引起肝脏损害,致转氨酶、胆红素升高,临床应用中注意该项副作用。
Objective To investigate the hepatotoxicity of FK506. Methods Two cases of renal transplantation after application of FK506, there aminotransferase, bilirubin increased. Results Only one patient recovered liver function after stopping drug treatment. The other patient was stopped after stopping drug treatment and recovered after liver protection treatment. Conclusion FK506 can cause liver damage, causing elevated aminotransferase and bilirubin, and pay attention to this side effect in clinical application.