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髓过氧化物酶(MPO)主要存在于嗜中性粒细胞和单核细胞内,其功能主要与抗菌有关。本文报告了一例患糖尿病并伴有白色念珠菌性肝脓肿的38岁的葡萄牙妇女。作者对此患者和13位正常人的粒细胞的代谢、吞噬和抗菌性能分别作了测定和比较。结果发现,患者粒细胞对大肠杆菌的吞噬能力正常;抗金黄色葡萄球菌的性能稍降低;抗白色念珠菌的性能则严重受损。患者粒细胞在进行吞噬时的耗氧量比正常人高60％。作者进一步对患者及其27位亲属的粒细胞内的MPO作了生化测定,结果发现患者母亲和
Myeloperoxidase (MPO) is mainly present in neutrophils and monocytes, and its function is mainly related to antibacterial. This article reports a 38-year-old Portuguese woman with diabetes mellitus and white candida liver abscess. The author of this patient and 13 normal human granulocyte metabolism, phagocytosis and antibacterial properties were measured and compared. The results showed that patients with normal granulocytes phagocytosis of Escherichia coli; anti-Staphylococcus aureus performance slightly lower; anti-Candida albicans performance is severely impaired. Patients with phagocytosis when the oxygen consumption of 60% higher than normal. The authors further biopsy MPO in the granulocytes of patients and their 27 relatives and found that mothers and