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首先以离子液体1-丁基-3-甲基咪唑氯盐([BMIM]Cl)为反应介质和催化剂,羰基二咪唑为偶联剂,均相合成了壳寡糖接枝聚乙烯亚胺共聚物(COS-g-PEI);其次,以COS-g-PEI为稳定剂,硝酸银为前驱体,硼氢化钠为还原剂,采用原位还原法制备了COS-g-PEI修饰纳米银复合粒子(Ag NPs@-COS-g-PEI)。采用IR、~1HNMR对聚合物结构进行表征,结果证实成功合成了COS-g-PEI接枝共聚物;UV-Vis、TEM结果表明,成功制备了稳定的Ag NPs@-COS-g-PEI复合粒子。通过滤纸片法和牛津杯法测试了COS-g-PEI及Ag NPs@-COS-g-PEI对金黄色葡萄球菌和大肠杆菌的抗菌性能,Ag NPs@-COS-g-PEI的抑菌圈直径均比COS-g-PEI大,结果表明,Ag NPs与COS-gPEI有机结合大大提高了抗菌性能。
Firstly, chitooligosacryl-grafted polyethyleneimine copolymerization was carried out homogeneously with ionic liquid 1-butyl-3-methylimidazolium chloride ([BMIM] Cl) as the reaction medium and catalyst and carbonyldiimidazole as coupling agent (COS-g-PEI). Secondly, COS-g-PEI modified nanosilver composite was prepared by in situ reduction using COS-g-PEI as stabilizer, silver nitrate as precursor and sodium borohydride as reductant. Particles (Ag NPs @ -COS-g-PEI). The structure of the polymer was characterized by IR and 1HNMR. The results showed that COS-g-PEI graft copolymer was successfully synthesized. The results of UV-Vis and TEM showed that Ag NPs @ -COS-g-PEI particle. The antibacterial activity of COS-g-PEI and Ag NPs @ -COS-g-PEI against Staphylococcus aureus and Escherichia coli was tested by filter paper method and Oxford cup method. The inhibition zone of Ag NPs @ -COS-g-PEI Diameter larger than COS-g-PEI, the results show that Ag NPs and COS-gPEI organically increased antibacterial properties.