论文部分内容阅读
目的评价颌下腺移位对防治头颈鳞癌放疗后口干燥症的临床疗效。方法 41例头颈鳞癌患者随机分为对照组20例和观察组21例,对照组仅行放射治疗,观察组放疗前先行单纯颌下腺移位术或肿瘤根治+颌下腺移位术,放疗时颏下区设置挡块。放疗前及放疗后6个月行~(99m)Tc核素扫描,了解患者颌下腺功能;放疗后3、6个月行口干程度问卷调查,观察口干燥症发生情况,并进行2组间比较。结果放疗前2组患者颌下腺功能均正常;放疗后6个月,观察组颌下腺摄取、分泌功能基本正常率(71.4%、66.7%)高于对照组(25.0%、20.0%)(P<0.01);放疗后3、6个月,观察组中、重度口干燥症发生率(33.3%、23.8%)均低于对照组(90.0%、80.0%)(P<0.01)。结论颌下腺移位对防治头颈鳞癌放疗后口干燥症疗效确切,可有效改善患者生存质量。
Objective To evaluate the clinical effect of submandibular gland displacement on prevention and treatment of dry mouth disease after radiotherapy of head and neck squamous cell carcinoma. Methods Totally 41 patients with head and neck squamous cell carcinoma were randomly divided into control group (n = 20) and observation group (n = 21). The control group received radiotherapy only. The observation group received simple submandibular gland shunt or tumor radical + submandibular gland shift before radiotherapy. Zone setting stop. Radiotherapy before and 6 months after radiotherapy 99m Tc radionuclide scan to understand the patient’s submandibular gland function; 3,6 months after radiotherapy, the degree of dry mouth questionnaire survey to observe the occurrence of xerostomia, and compared between the two groups . Results The submandibular gland function was normal in the two groups before radiotherapy. At 6 months after radiotherapy, the basic normal rate of semen uptake and secretion in the submandibular gland of the observation group was 71.4% and 66.7% higher than that in the control group (25.0% and 20.0%, P <0.01) (33.3%, 23.8%) in the observation group were lower than those in the control group (90.0%, 80.0%) at 3 and 6 months after radiotherapy (P <0.01). Conclusion Submandibular gland displacement is effective in preventing and treating xerostomia after radiotherapy of head and neck squamous cell carcinoma, which can effectively improve the quality of life of patients.