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目的:观察乌梅消食颗粒对缺铁性贫血(IDA)患者T细胞亚群的紊乱的治疗疗效。方法:对不同诱因导致的缺铁性贫血患者共85例随机分为两组,治疗组采用乌梅消食颗粒联合乳酸亚铁口服液,对照组采用安慰剂加乳酸亚铁口服液治疗,采用三色直接荧光法流式细胞技术进行T细胞亚群检验,对比二者治疗前后是否具有差异。判断联合治疗及单药治疗对细胞免疫是否具有相关影响。结果:与铁剂单药对照组相比,联合治疗组外周血中CD_3~+、CD_3~+CD_4~+淋巴细胞计数回升更快,CD_4~+/CD_8~+比值较治疗前提升更加明显(P<0.01),联合组CD_3~+CD_8~+淋巴细胞计数降低更加明显(P<0.05)。与治疗前相比,两组患者细胞免疫紊乱均有所改善(P<0.05)。结论:缺铁性贫血患者存在细胞免疫紊乱,而且这种T细胞亚群异常可以被铁剂纠正,联合乌梅消食颗粒可以加速这种细胞免疫异常的恢复。
Objective: To observe the therapeutic effect of WuMei Xiaoshi Granule on the disorder of T cell subsets in patients with iron deficiency anemia (IDA). Methods: A total of 85 cases of iron deficiency anemia caused by different causes were randomly divided into two groups. The treatment group was treated with WuMei Xiaoyu Granules combined with ferrous lactate, the control group with placebo plus ferrous lactate oral solution, Direct fluorescence method flow cytometry T cell subsets test, compared with the two before and after treatment whether there is a difference. To determine whether combination therapy and monotherapy have a relevant effect on cellular immunity. Results: Compared with the single drug control group, the counts of CD_3 ~ + and CD_3 ~ + CD_4 ~ + in the peripheral blood of the combined treatment group rose more rapidly and the ratio of CD_4 ~ + / CD_8 ~ + increased more significantly than that before treatment P <0.01). The decrease of CD_3 ~ + CD_8 ~ + lymphocyte count in the combination group was more obvious (P <0.05). Compared with pre-treatment, the cellular immune disorder in both groups improved (P <0.05). CONCLUSIONS: There is cellular immune disorder in patients with iron deficiency anemia, and the abnormality of this T cell subsets can be corrected by iron agents. Combined with WuMei Xiaoyong granules can accelerate the recovery of this cellular immune abnormality.