Merch Sharp实验室及Dohme实验室的科学家们从牛链霉菌(Streptomyces cattleya)的肉汤培养液中发现硫霉素.硫霉素有广泛抗菌活性,且对青霉素及头孢菌素有抗药性的细菌同样有效.遗憾的是硫霉素化学结构不稳定,不适于作为药物.然而硫霉素稳定的半合成衍生物结晶状N-亚氨甲基衍生物MK-787(现称为N-亚氨甲基硫霉素,Imipenem),在溶液中非常稳定,完全适合于临床应用.实验结果业已表明N-亚氨甲基硫霉素 Scientists at Merch Sharp Laboratory and Dohme Laboratories have found that spiramycin is found in broth cultures of Streptomyces cattleya, which has broad antibacterial activity and is resistant to penicillins and cephalosporins Equally potent.Unfortunately, the chemical structure of thiophanate is not stable, not suitable as a drug.However, the stable semi-synthetic derivatives of thiophancianic acid crystalline N-iminomethyl derivative MK-787 (now known as N- Methylthiomycin, Imipenem), is very stable in solution and is well suited for clinical applications.Experimental Results It has been shown that N-methylthiothiomycin