钙化性主动脉瓣狭窄是老年人最常见的心脏瓣膜疾病,其病理特征主要是瓣叶的局灶性钙化和广泛纤维性增厚,发病机制过去一直被认为是退行性不可修复的劳损过程,近年来多项研究表明钙化性主动脉瓣狭窄是积极主动调控过程。目前发现主要有炎性细胞浸润、脂质沉积、凋亡结节形成、骨形成、细胞外基质的重塑、血管形成及肾素血管紧张素系统等机制参与。本文就钙化性主动脉瓣狭窄发病机制的研究进展及相应的治疗研究做简单的阐述。 Calcification Aortic stenosis is the most common heart valve disease in the elderly, and its pathological features are mainly focal calcification and extensive fibrous thickening of the valve leaflets. The pathogenesis has historically been regarded as a degenerative and irreversible strain-up process. In recent years, a number of studies have shown that calcification of aortic stenosis is a proactive process of regulation. At present it is found that inflammatory cell infiltration, lipid deposition, formation of apoptotic nodules, bone formation, remodeling of extracellular matrix, angiogenesis and renin-angiotensin system are involved. This article on the pathogenesis of calcific aortic stenosis research advances and the corresponding treatment of a simple exposition.