烟、酒等刺激因素的长期作用能引起口腔粘膜白斑,白斑可以发生癌变,故口腔癌与吸烟等刺激因素有关。因而,口腔粘膜的白斑长期来为人们所关注。可是,在临床上却较少见到“吸烟—白斑—癌”这种三步曲的典型病例。另外我们在临床工作中还发现不少的粘膜白斑患者,毫无症状,甚至本人并不知道口腔粘膜有白斑存在。Sandstead对“无症状”的口腔中广泛性灰白色的粘膜损害称之为“白色损害”。有些白斑患者并不存在烟或其它明显的刺激因素。由烟、酒刺激引起的口腔粘膜白斑和并非烟、酒刺激引起的白色损 The long-term effects of smoke, alcohol and other stimulating factors can cause oral leukoplakia, white spots can be cancerous, so oral cancer and smoking and other stimulating factors. Therefore, white spots on the oral mucosa have long been of concern to people. However, the typical case of the three-step “smoking-white spot-cancer” is rarely seen clinically. In addition, we also found a lot of patients with leukoplakia in the clinical work, no symptoms, and even I do not know that oral mucosa has white spots. Sandstead called the “asymptomatic” mucosal lesions that are extensively gray in the mouth as “white lesions.” Some patients with leukoplakia do not have smoke or other obvious stimuli. White mucous membranes caused by smoke and alcohol stimulation and white damage caused by smoke and alcohol stimulation