环胞菌素(cyclosporine.下称“环胞”)是1970年从两种真菌株分离得到的中性环状多肽化合物。从1978年临床试用以来,已证实其有强效免疫抑制作用并相对缺乏骨髓毒性,对器官移植术的成功有重要作用。“环胞”产生免疫抑制作用的确切机理尚不明了。一般认为其药理活性是通过专属抑制 T—淋巴细胞功能而产生,对 B—淋巴细胞作用很小。 Cyclosporine (hereinafter referred to as “circular cell”) is a neutral cyclic peptide compound isolated from two fungal strains in 1970. Since its clinical trials in 1978, it has been shown to have potent immunosuppression and a relative lack of myelotoxicity, which plays an important role in the success of organ transplantation. The exact mechanism by which “cyclopeptide” produces immunosuppressive effects is not known. Generally believed that its pharmacological activity is produced by exclusive inhibition of T-lymphocyte function, the role of B-lymphocytes is small.