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干扰素调节因子3(interferon regulatory factor-3,IRF-3)是调节Ⅰ型干扰素基因表达的关键转录因子,它的活化将影响IFN基因的表达。IRF-3的磷酸化受多条信号转导通路及相关分子的调控。在有关的调控中,RIG-I/MDA-5-MAVS与IRF-3的活化关系较为密切,RIG-I/MDA-5识别病原相关分子模式(PAMP),经中间蛋白质MAVS激活下游激酶复合体TBK1/IKKε,通过不同机制活化转录因子IRF-3。在此通路中,有TRAF3、NEMO、TRADD等分子参与,最近有研究发现,TRAF5、STING、WDR5亦参与调控,在调节IRF-3的活化过程中发挥重要作用。通过对IRF-3激活的研究,将有助于阐明病毒诱导机体产生先天性免疫和特异性免疫的分子机制。
Interferon regulatory factor-3 (IRF-3) is a key transcription factor that regulates type I interferon gene expression. Its activation affects the expression of IFN gene. Phosphorylation of IRF-3 is regulated by multiple signal transduction pathways and related molecules. In the regulation of RIG-I / MDA-5-MAVS and IRF-3 activation is more closely related to RIG-I / MDA-5 recognition of pathogen-associated molecular patterns (PAMP), the activation of downstream protein kinase MAVS complex TBK1 / IKKε activates transcription factor IRF-3 through different mechanisms. In this pathway, there are TRAF3, NEMO, TRADD and other molecules involved in the recent studies have found that TRAF5, STING, WDR5 also involved in the regulation, in regulating the activation of IRF-3 play an important role. The research on IRF-3 activation will help elucidate the molecular mechanism of virus-induced innate and specific immunity.