论文部分内容阅读
目的研究雄激素受体(AR)在胃癌组织中的表达及临床意义。方法选取经手术切除并经病理证实的早、进展期胃癌73例,免疫组化SP法染色检测AR在胃癌组织中的表达,分析与临床病理指标、预后的关系。结果胃癌组织AR阳性率为39.73%,且与胃癌的组织学分级及淋巴结转移呈负相关。Kaplan-Meier(卡普兰-迈耶曲线)生存分析显示,AR阳性表达者的累计生存率明显高于阴性表达者。AR表达、肿瘤大小、病期、淋巴结转移及浸润深度均影响胃癌预后;其中的淋巴结转移和浸润深度是评估预后的独立指标。结论AR在一定程度上较早地提示胃癌的预后,它的过度表达提示胃癌预后良好。胃癌AR阳性表达可为其内分泌治疗提供参考。
Objective To study the expression of androgen receptor (AR) in gastric carcinoma and its clinical significance. Methods Totally 73 cases of advanced and advanced gastric cancer were excised and pathologically confirmed. The expression of AR in gastric cancer tissues was detected by immunohistochemical SP method. The relationship between AR and clinicopathological parameters and prognosis was analyzed. Results The positive rate of AR in gastric cancer tissue was 39.73%, which was negatively correlated with histological grade and lymph node metastasis. Survival analysis of Kaplan-Meier curves showed that the cumulative survival rate of AR positive expression was significantly higher than that of negative expression. AR expression, tumor size, disease stage, lymph node metastasis and depth of invasion affect the prognosis of gastric cancer. The lymph node metastasis and depth of invasion are independent prognostic indicators. Conclusions AR to some extent prompted the prognosis of gastric cancer, its overexpression of gastric cancer prognosis is good. The positive expression of AR in gastric cancer may provide reference for its endocrine therapy.