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目的：研究柳珊瑚酸（Ｓｕｂ）、Ｎ柳珊瑚酰胺ＮＮ二环己基脲（ＳｕｂＤＵ），Ｎ环己基柳珊瑚酰胺（ＮＣＳ）在影响记忆与抗胆碱酯酶（ＡＣｈＥ）作用间的关系．方法：在被动回避操作装置上测定小鼠ｉｐＳｕｂ或其衍生物后的跳台潜伏期（ＳＤＬ）和逃避潜伏期（ＥＬ）；比色法测定ＡＣｈＥ活力．结果：Ｓｕｂ１９，ＳｕｂＤＵ３０和Ｐｈｙｓ０１５ｍｇ·ｋｇ－１分别使成年小鼠的ＳＤＬ延长１９５％，２７１％和２１０％，ＥＬ缩短５６％，６１％和３３％；前二者尚同时使小鼠全脑匀浆ＡＣｈＥ活力各降低１７％和１９％．大于上述剂量时，Ｓｕｂ和ＳｕｂＤＵ对ＳＤＬ和ＥＬ的作用依剂量地减弱．Ｓｕｂ１９，ＳｕｂＤＵ２０和Ｐｈｙｓ０１５ｍｇ·ｋｇ－１还可使老年小鼠的ＳＤＬ各延长１８７％，２０９％和１５２％，ＥＬ各缩短５２％，６２％和５７％．三药尚明显改善由环己酰亚胺或东莨菪碱产生的记忆保持损害．ＮＣＳ无上述作用．结论：Ｓｕｂ和ＳｕｂＤＵ对记忆的改善作用与其抗ＡＣｈＥ有关．
OBJECTIVE: To study the effects of salicylic acid (Sub), N-salicylate NNdicyclohexylurea (SubDU) and Ncyclohexyllactam (NCS) on the memory and anticholinergic Relationship between enzyme (AChE) effects. Methods: The jumping latency (SDL) and escape latency (EL) of mice ipSub or its derivatives were measured on passive avoidance device. The activity of AChE was determined by colorimetric assay. Results: Sub19, SubDU30 and Phys015 mg · kg-1 prolonged the SDL of adult mice by 195%, 271% and 210%, and EL by 56%, 61% and 33% respectively. At the same time, the activity of AChE in whole brain homogenate decreased by 17% and 19% respectively. Above the above dose, the effect of Sub and Sub-DU on SDL and EL diminishes in dose. Sub19, SubDU20 and Phys015 mg · kg-1 also prolonged the SDL of aged mice by 187%, 209% and 152% respectively, while the EL shortened by 52%, 62% and 57% respectively. Trials have also significantly improved memory retention by cycloheximide or scopolamine. N CS no such effect. Conclusion: The improving effect of Sub and Sub-DU on memory is related to its anti-AChE.