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补骨脂素(Psoralen)化合物是一种光敏剂,已在皮肤科临床上用于治疗牛皮癣及白癜风。光疗系指通常所用的补骨脂素-长波紫外光放射(简称为P-UVA)治疗,包括摄入8-甲氧补骨脂素(简称为8-MOP)或其相似的化合物,然后用紫外线(波长320—390 mμ)作短时间照射。当给动物(鼠、鲨鱼或猴)单次剂量,2小时后即可在眼组织中发现8-甲氧补骨脂素(8-MOP);如果同时用充分紫外线照射,则8-MOP可以籍光与晶体蛋白及DNA结合。由于人及多数哺乳类动物的
Psoralen compounds are photosensitizers that have been clinically used in dermatology to treat psoriasis and vitiligo. Phototherapy refers to the commonly used psoralen-long wave ultraviolet radiation (P-UVA) treatment, which involves the ingestion of 8-methoxypsoralen (abbreviated as 8-MOP) or its analogous compound, followed by UV (wavelength 320-390 mμ) for a short time irradiation. 8-Methoxypsoralen (8-MOP) can be found in ocular tissue 2 hours after a single dose of the animal (rat, shark, or monkey); 8-MOP can be found in both ocular tissues if irradiated with sufficient UV light Ji light and crystal protein and DNA binding. Because of people and most mammals