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内皮素作为一类新发现的活性多肽,可促进癌细胞 DNA 合成,抑制细胞凋亡并促进新生血管的生成;运用内皮素-1受体抑制剂,有望在抗肿瘤血管生成中发挥有益的作用。本文就内皮素及其受体在喉肿瘤中的研究作一概述。
As a newly discovered active peptide, endothelin can promote DNA synthesis of cancer cells, inhibit apoptosis and promote neovascularization. Endothelin-1 receptor inhibitor is expected to play a beneficial role in anti-tumor angiogenesis . This article summarizes the research of endothelin and its receptor in laryngeal neoplasms.