Sine oculis homeobox homolog(Six)基因为同源盒基因,最早发现于果蝇,是一种在多种生物中均有表达且高度保守的转录因子,不仅参与调控胚胎的正常发育和器官形成,还参与多种肿瘤的发生发展~([1])。胃癌细胞Six1高表达增加胃癌细胞的侵袭能力~([2])。在胰腺癌细胞中,Six1能够通过上调细胞周期蛋白D1(cyclin D1)的表达促进胰腺癌细胞的增殖~([3])。Six1的过表达是结直肠 The SoyOculis homeobox homolog (Six) gene is a homologous box gene, originally found in Drosophila. It is a highly expressed and highly conserved transcription factor in many organisms. It not only regulates the normal embryo development and organ formation, but also Involved in the development of a variety of tumors ~ ([1]). Six1 high expression of gastric cancer cells increase the invasiveness of gastric cancer cells ~ ([2]). In pancreatic cancer cells, Six1 can promote the proliferation of pancreatic cancer cells by up-regulating the expression of cyclin D1 (3). Six1 overexpression is colorectal