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Graves眼病(GO)与甲状腺自身免疫反应之间的关系尚未完全明了,甲状腺抗原可能是它们的主要桥梁,细胞因子在其中也发挥很重要的作用。GO急性期以Th1型细胞因子如干扰素(IFN)-γ、白介素(IL)-1、IL-2、转化生长因子(TGF)-β或肿瘤坏死因子(TNF)-α等产生为主,与眼外肌增大有关,是致免疫细胞因子;慢性期以,Th2型细胞因子如IL-4、IL-6及IL-10等产生为主,累及球后脂肪组织,是抗免疫细胞因子。因此,急性期的Th1型细胞因子和慢性期的Th2型细胞因子可影响GO的发生和发展。
The relationship between Graves’ ophthalmia (GO) and the thyroid autoimmune response is not yet fully understood, and thyroid antigens may be their primary bridge in which cytokines also play an important role. In the acute stage of GO, the production of Th1-type cytokines such as interferon (IFN) -γ, interleukin (IL) -1, IL-2, transforming growth factor (TGF) -β or tumor necrosis factor (TNF) And extraocular muscle increased, is caused by immune cytokines; chronic phase, Th2-type cytokines such as IL-4, IL-6 and IL-10-based production, involving the posterior globe adipose tissue, anti-immune cytokines . Therefore, the acute phase of Th1-type cytokines and chronic phase of Th2-type cytokines can affect the occurrence and development of GO.