Notch基因首次发现于1917年,因其功能部分缺失可导致果蝇翅缘出现缺口,故被命名为Notch。Notch信号通路是一条影响细胞命运的、保守而重要的信号转导通路,通过局部细胞间的相互作用来广泛调节脊椎和无脊椎动物的胚胎及成年个体的发育和内环境稳定[1]。目前大量研究证明,除在正? The Notch gene was first discovered in 1917, and was named Notch because of missing parts of its function leading to a gap in the fins margin of the fruit fly. The Notch signaling pathway is a conserved and important signal transduction pathway that affects the fate of cells, and widely regulates the development and homeostasis of embryos and adult individuals in vertebrates and invertebrates through local cell-cell interactions [1]. At present a large number of studies have shown that, except in positive?