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目的本实验研究改进型同轴电纺在药物缓释纳米纤维开发上的应用。方法以乙基纤维素为成纤聚合物基材、以阿魏酸为模型药物、以乙醇为环流鞘液实施溶剂环流同轴电纺工艺,制备出载药乙基纤维素纳米纤维,进行系列表征分析。结果所实施的改进型同轴电纺能够不堵塞纺丝头、连续而平稳地进行纳米纤维制备,场发射扫描电镜观察纳米纤维直径可以通过鞘液流量进行调控,晶体衍射和红外分析结果表明,乙基纤维素能与阿魏酸通过氢键相互作用,使得阿魏酸以无定形态存在于纳米纤维基材中,体外释放结果表明,阿魏酸能够通过扩散机制进行缓释。结论溶剂环流同轴电纺技术能够为新型药物缓释给药系统的开发提供有效工具。
Objective This experiment is to study the application of modified coaxial electrospinning in the development of drug-extended nanofibers. Methods Ethylcellulose as the fiber-forming polymer substrate, with ferulic acid as a model drug, ethanol as a circulating sheath solvent circulation coaxial electrospinning process, prepared drug-loaded ethyl cellulose nanofibers, series Characterization analysis. Results The modified coaxial electrospinning can not only block the spinning head but also make the nanofibers continuously and smoothly. The diameter of the nanofibers can be regulated by the field emission scanning electron microscope. The results of crystal diffraction and infrared analysis show that, Ethyl cellulose can interact with ferulic acid through hydrogen bonds, making ferulic acid exist in amorphous state in the nanofibrous matrix. The in vitro release results show that ferulic acid can be slowly released through the diffusion mechanism. Conclusion The solvent circulation coaxial electrospinning technology can provide an effective tool for the development of new drug delivery system.