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近年来有报导在动物中发现与人类乙型肝炎病毒(HBV)有关的肝炎病毒。1983年我们用R—PHA法对7种动物的417份血清作HBsAg类似物检测,经中和试验阳性4份,其中112份鸡、97份犬、155份鼠和1份黄猄各有1份阳性,其滴度分别为1:16、1:4、1:16和1:4,阳性检出率为0.96%。另27份鸭、21份鹅和4份羊均为阴性。用ELISA法中和试验复检了上述可疑及阳性标本34份,其中18份鸡有3份,4份鸭有1份和羊、犬,黄猄各1份阳性,阳性检出率为20.59%;另3份鹅和6份鼠则阴性。曾有报告阐述土拨鼠肝炎病毒、地松鼠肝炎病毒和鸭肝炎病毒的形态、大小及其基因组与HBV相似,亦具DNA多聚酶活力,侵犯肝脏且有持续感染现象,感染的动物血液中存在相应的表面抗原物质。最近还
In recent years, it has been reported that hepatitis virus associated with human hepatitis B virus (HBV) is found in animals. In 1983, we detected HBsAg analogs in 417 sera of 7 animals by R-PHA, 4 of which were positive by neutralization test, of which 112 were chickens, 97 dogs, 155 rats and 1 yellow catfish each had 1 The positive titer was 1: 16, 1: 4, 1:16 and 1: 4 respectively. The positive detection rate was 0.96%. The other 27 ducks, 21 geese and 4 sheep were negative. 34 samples of the suspicious and positive samples were retested by ELISA neutralization test. Among them, 3 samples of 18 chicken, 1 copy of 4 ducks and 1 copy of sheep, dog and yellow catfish were positive, the positive detection rate was 20.59% ; The other three geese and 6 mice were negative. There have been reports on the morphology, size and genome of the woodchuck hepatitis virus, ground squirrel hepatitis virus and duck hepatitis virus, which are similar to those of HBV. They also have the activity of DNA polymerase, invade the liver and have a persistent infection, and there is a corresponding Of surface antigenic material. Recently also