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两种缓释制剂处方Ⅰ和Ⅱ均含甲巯丙脯酸25mg和抗坏血酸125mg,含大豆油分别为175和142.9mg及单硬脂酸甘油酯50和7.1mg,装入胶囊,分別与含相同量主药的普通片作生物利用度对比研究。受试者随机分两组,按交叉试验原理于标准早餐后30min服用缓释制剂或普通片,按规定间隔取血,尿样品。处方Ⅰ用5名男性受试者得血浓达峰时(T_(max))为4h,尿药达峰时(T_(max-u))为2～4 h,而普通片
Both sustained-release formulations prescriptions I and II contain captopril 25mg and ascorbic acid 125mg, containing soybean oil 175 and 142.9mg and glyceryl monostearate 50 and 7.1mg, respectively, into the capsule, respectively, containing the same The comparison of the bioavailability of the main tablets of traditional Chinese medicine. Subjects were randomly divided into two groups, according to the principle of cross-testing in the standard 30min after taking sustained-release preparations or ordinary tablets, blood samples at regular intervals, urine. Prescription Ⅰ with 5 male subjects peak blood concentration (T_ (max)) for 4h, urine peak (T_ (max_u)) for 2 ~ 4h, while the ordinary tablets