论文部分内容阅读
金黄色葡萄球菌是临床常见感染疾患致病菌,了解金黄色葡萄球菌对临床常用的β-内酰胺类抗生素的敏感性,对合理使用抗生素及时控制金黄色葡萄球菌感染是十分重要的.本文报告了北京地区临床分离致病金黄色葡萄球菌209株对16个β-内酰胺类抗生素敏感性研究结果.比较了16个抗生素对金黄色葡萄球菌的MIC范围、MIC_(50)、MIC_(90)、NIC_(mode)、MIC_(GM),并用I_(50)的指标比较客观地反映出同类药之间抗菌作用的差异.研究结果表明:青霉素类Oxacillin、Cloxacillin抗金黄色葡萄球菌的作用最强,两药的MIC_(60)、MIC_(90)相同,分别为0.25、0.5mg/L,但Cloxacillin的I_(50)值为0.20mg/L铰Oxacillin的0.23mg/L稍低,表明Cooxacillin的抗茵作用较Oxacillin好.Ampicillin与PenicllinG的抗菌作用相似,由于PencillinG临床常用剂量血浓度不高,PenicillinG临床抗金黄色葡萄球菌的疗效可能不理想.四种酰脲类抗生素抗菌作用的强弱次序是Furbenicillin、Mezlocillin、Azlocillin、Piperacillin,在多种细菌混合感染时选用Furbenicillin可能更好.Carbenicillin抗金黄色葡萄球菌的作用最差.头孢菌素类抗生素,第一代头孢菌素Cephalothin、Cefazolin抗金黄色葡萄球菌的作用明显优于第三代头孢菌素,一、二、三代头孢菌素随抗革蓝氏阴?
Staphylococcus aureus is a common clinical infection pathogens, to understand the Staphylococcus aureus commonly used in clinical β-lactam antibiotics sensitivity, the rational use of antibiotics and timely control of Staphylococcus aureus infection is very important.This paper reports The results of the study on the sensitivity of 209 isolates of pathogenic Staphylococcus aureus to 16 β-lactam antibiotics in Beijing area were compared.The MIC range, MIC 50, MIC 90 of the 16 antibiotics against Staphylococcus aureus were compared, , NIC_ (mode), MIC_ (GM), and the index of I_ (50) objectively reflected the difference of antibacterial effect among similar drugs.The results showed that the antibacterial activity of penicillins Oxacillin and Cloxacillin against Staphylococcus aureus was the strongest , The MIC_ (60) and MIC_ (90) of the two drugs were the same, 0.25,0.5 mg / L respectively, but the I_ (50) value of Cloxacillin was 0.23 mg / L slightly lower for 0.20 mg / L Hinge Oxacillin, indicating that Cooxacillin Antibacterial effect better than Oxacillin.Ampicillin and PenicllinG antibacterial effect similar to penicillinG clinical common dose of blood concentration is not high, PenicillinG clinical anti-Staphylococcus aureus efficacy may not be ideal.Antimicrobial antibacterial Furbenicillin, Mezlocillin, Azlocillin, and Piperacillin may be the best choice when using mixed bacterial infection with Furbenicillin.Carbenicillin has the poorest anti-Staphylococcus aureus activity.Cephalosporins antibiotics, the first-generation cephalosporin Cephalothin , Cefazolin anti-Staphylococcus aureus was significantly better than the third-generation cephalosporins, one, two, three cephalosporins with anti-leather blue shade?