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PGLC为聚酯型生物降解高分子材料 ,可在体内自行降解及被机体代谢 ,因此本品可作为植入体内的长效药物载体。为保证使用的安全性 ,对本品进行致突变试验研究。本文应用鼠伤寒沙门氏菌基因回复突变试验观察PGLC的遗传安全性。试验表明 :PGLC对四个菌株各剂量组的回复菌落数都未
PGLC is a polyester biodegradable polymer material that can be degraded in the body and metabolized by the body. Therefore, PGLC can be used as a long-acting drug carrier for implantation into the body. In order to ensure the safety of the use of mutagenicity test of this product. In this paper, Salmonella typhimurium gene mutation test to observe the genetic safety of PGLC. Experiments show that: PGLC on the four strains of each dose group did not restore the number of colonies