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探讨低血压复苏在出血未控制的创伤失血性休克治疗中的意义。建立创伤性休克动物模型 ,随机分为不复苏组、传统复苏组和低压复苏组 ,于创伤前后测定凝血酶原时间、部分凝血活酶时间及肝、小肠、骨骼肌的组织氧分压变化 ,监测生命体征 ,记录存活时间。结果显示 ,传统复苏组休克期出血量显著多于其他两组 ,凝血酶原时间、部分凝血活酶时间延长 ,而低压复苏组可显著改善组织氧分压 ,延长存活时间。提示低血压复苏治疗更能改善出血未控制的创伤性休克大鼠的预后。
To investigate the significance of hypotension resuscitation in the treatment of uncontrolled traumatic hemorrhagic shock. The animal models of traumatic shock were established and randomly divided into non-resuscitation group, traditional resuscitation group and low-pressure resuscitation group. Prothrombin time, partial thromboplastin time, changes of tissue oxygen partial pressure in liver, small intestine and skeletal muscle were measured before and after trauma. Vital signs were monitored and survival was recorded. The results showed that in the traditional resuscitation group, bleeding volume in shock period was significantly more than that in the other two groups. Prothrombin time and partial thromboplastin time prolonged. However, low-pressure resuscitation group significantly improved tissue oxygen partial pressure and prolonged survival time. Prompt hypotension resuscitation therapy can improve the prognosis of uncontrolled traumatic shock rats.