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目的：探讨适合基层医院适用的最佳溶栓途径。方法：226例大脑中动脉供血急性脑梗死病人，按入院先后次序随机分为动脉组116例与静脉组110例，分别采用经颈内动脉及静满尿激酶10万U，每日1次，共7天；其它辅助治疗两组相同，14天为一疗程。结果：动脉组基本治愈45例，显著进步37例，进步19例，总有效率87．07％。其基本治愈率及总有效率均显著高于对照组，动脉络出血1．72%，显著低于静脉组（P＜0．05）。结论：经颈内动脉滴注尿激酶溶栓疗效好、副作用小、安全可靠、简单易行，值得推广。
Objective: To explore the best suitable for primary hospital thrombolysis approach. Methods: A total of 226 patients with acute cerebral infarction with middle cerebral artery were randomly divided into arterial group (n = 116) and intravenous group (n = 110) according to the sequence of hospital admission. The patients were given 100,000 U of urokinase via internal carotid artery and intravenous infusion once daily, A total of 7 days; other adjuvant treatment of the same two groups, 14 days for a course of treatment. Results: 45 cases were basically cured in arterial group, 37 cases improved significantly and 19 cases improved. The total effective rate was 87.07%. The basic cure rate and total effective rate were significantly higher than the control group, arteries bleeding 1.72%, significantly lower than the vein group (P <0.05). Conclusion: Thrombolytic therapy of urokinase through internal carotid artery has good curative effect, less side effects, safe and reliable, simple and easy to be implemented and worthy of popularization.