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目的:分析拓扑替康联合高三尖杉酯碱、阿糖胞苷(THA方案)用于急性白血病强化治疗的毒副作用。方法:THA方案治疗缓解后急性白血病10例。结果:白细胞于化疗结束时较化疗前显著下降,非血液毒性多为Ⅰ级￣Ⅱ级胃肠道反应。结论:THA方案用于缓解后强化治疗,致三系变化作用轻微,副反应较少,是一个可以接受的强化治疗方案。
OBJECTIVE: To analyze the toxicities and side effects of topotecan combined with homoharringtonine and cytarabine (THA regimen) in the intensive treatment of acute leukemia. Methods: THA regimen in the treatment of acute leukemia in 10 cases. Results: Leukocytes decreased significantly at the end of chemotherapy compared with those before chemotherapy. Non-hematologic toxicity was mostly grade Ⅰ ~ Ⅱ gastrointestinal reactions. Conclusion: The THA regimen is used to relieve post-intensive treatment, resulting in mild changes in three lines and few side effects. This is an acceptable intensive treatment regimen.