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三苯氧胺是一种非类固醇抗雌激素药物,有抗乳腺癌作用,被选作治疗许多依赖雌激素的转移性乳腺癌。在长期大剂量三苯氧胺治疗中已有视网膜病和角膜病的报告。本文首次对小剂量三苯氧胺治疗后眼中毒的发生率和病程作了前瞻性调查。患者与方法1986年1月～1990年12月间希腊Ioannina大学医学系肿瘤科的63例癌症患者接受每天20 mg三苯氧胺治疗。患者平均年龄58岁(32～82岁),只有一例男性,60例乳腺癌,3例胰腺癌。中位服药时间25个月(6～51个月),中位总剂量44g(3.6～30g)。治疗初眼科学检查有娇正的视敏度、裂隙灯检查、Gold-mann角膜眼压测量、Amlser滤光栅试验、视野检查和散瞳后眼底镜检查。以后每6个月作一次眼科学检查。有脑转移、长期糖尿病、严重
Tamoxifen, a non-steroidal anti-estrogen, has anti-breast cancer effects and has been selected for the treatment of many estrogen-dependent metastatic breast cancers. There have been reports of retinopathy and corneal disease in long-term high-dose tamoxifen therapy. This is the first study of the incidence and duration of ocular poisoning after low-dose tamoxifen treatment was prospectively investigated. PATIENTS AND METHODS Sixty-three patients with cancer from the Department of Oncology, Department of Medicine, Ioannina University, Greece, from January 1986 to December 1990, received 20 mg of tamoxifen daily. The mean age of patients was 58 years (32-82 years), with only one male, 60 breast and 3 pancreatic cancer. Median medication time of 25 months (6 to 51 months), the median total dose of 44g (3.6 ~ 30g). First-time treatment of eye surgery have a correct visual acuity, slit lamp examination, Gold-mann corneal intraocular pressure measurement, Amlser filter grating test, visual field examination and mydriasis ophthalmoscopy. After every 6 months for an ophthalmological examination. Have brain metastases, long-term diabetes, severe