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目的:探讨特发性血小板减少性紫癜(ITP)患者血清中血小板生成调控因子血小板生成素(TPO)和转化生长因子β1(TGF-β1)的变化并探讨其临床意义。方法:采用双抗体夹心ELISA检测30例ITP和24例病例对照血清中的TPO和TGF-β1的水平。25例健康体检者为正常对照组。结果:ITP患者血清TPO水平与正常对照组相比无统计学意义(P>0.05),病例对照组TPO水平显著高于正常对照组(P<0.05)。ITP患者血清TGF-β1的含量显著高于正常对照组(P<0.05),病例对照组血清TGF-β1的含量与正常对照组相比无统计学意义(P>0.05),但显著低于ITP患者(P<0.05)。结论:检测ITP患者血清中的TPO及TGF-β1水平对其发病机制研究有重要意义。
Objective: To investigate the changes of platelet-producing regulatory factor thrombopoietin (TPO) and transforming growth factor-β1 (TGF-β1) in patients with idiopathic thrombocytopenic purpura (ITP) and to explore its clinical significance. Methods: The levels of TPO and TGF-β1 in 30 cases of ITP and 24 cases of control serum were detected by double antibody sandwich ELISA. Twenty-five healthy subjects were normal control group. Results: The level of serum TPO in ITP patients was not significantly different from that in normal control group (P> 0.05). The TPO level in case control group was significantly higher than that in normal control group (P <0.05). Serum levels of TGF-β1 in ITP patients were significantly higher than those in normal controls (P <0.05). Serum levels of TGF-β1 were not significantly different from those in normal controls (P> 0.05), but significantly lower than those in ITP Patients (P <0.05). Conclusion: The detection of serum TPO and TGF-β1 levels in patients with ITP is of great significance for the study of its pathogenesis.